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The exact mechanism by which gabapentin exerts its anticonvulsant activity is not known, methotrexate time to work but it does not appear to be related to its development as a GABA analog! In patients less than 50 years of age, the median time to cessation of new lesion formation was 2 days for those treated with VALTREX compared with 3 days for those treated with placebo?
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This, methotrexate dose limiting toxicity of course, depends on the underlying health of the patient and their age, among other factors!

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